Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists

J Med Chem. 1997 Oct 24;40(22):3504-7. doi: 10.1021/jm970343g.

Authors

T Tsuri¹, T Honma, Y Hiramatsu, T Okada, H Hashizume, S Mitsumori, M Inagaki, A Arimura, K Yasui, F Asanuma, J Kishino, M Ohtani

Affiliation

¹ Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.

PMID: 9357516
DOI: 10.1021/jm970343g

No abstract available

MeSH terms

Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Blood Platelets / drug effects
Bridged Bicyclo Compounds / administration & dosage
Bridged Bicyclo Compounds / chemistry
Bridged Bicyclo Compounds / pharmacology*
Guinea Pigs
Humans
Norbornanes / administration & dosage
Norbornanes / chemistry
Norbornanes / pharmacology*
Prostaglandin D2 / metabolism*
Receptors, Immunologic*
Receptors, Prostaglandin / administration & dosage*
Receptors, Prostaglandin / metabolism
Stereoisomerism
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents, Non-Steroidal
Bridged Bicyclo Compounds
Norbornanes
Receptors, Immunologic
Receptors, Prostaglandin
Prostaglandin D2
prostaglandin D2 receptor